Journal: International Journal of Pharmaceutics: X

Article Title: Double action of HPMCAS as a dry binder and precipitation inhibitor in ASD tablet formulations of nifedipine prepared by hot-melt extrusion

doi: 10.1016/j.ijpx.2025.100475

Figure Lengend Snippet: In vitro dissolution studies of ASD milled extrudates of NIF with and without pre-dissolved polymers in the dissolution media (mean ± SD, n = 3). A: ASD milled extrudates of NIF in dissolution media with no pre dissolved polymer (only PBS); B: NIF: AS-LMP (1:2) in PBS and dissolution media with different polymer solution of 100 μg/mL; C: NIF: AS-LMP (1:4) in PBS and dissolution media with different polymer solution of 100 μg/mL; D: NIF: PVP-VA64 (1:6) in PBS and dissolution media with different polymer solution of 100 μg/mL.

Article Snippet: NIF: PVP-VA64 (1:6) , 70 , 165.

Techniques: In Vitro, Dissolution, Polymer

Journal: International Journal of Pharmaceutics: X

Article Title: Double action of HPMCAS as a dry binder and precipitation inhibitor in ASD tablet formulations of nifedipine prepared by hot-melt extrusion

doi: 10.1016/j.ijpx.2025.100475

Figure Lengend Snippet: In vitro dissolution studies of ASD milled extrudates of NIF with and without pre-dissolved polymers in the dissolution media (mean ± SD, n = 3). A: ASD milled extrudates of NIF in dissolution media with no pre dissolved polymer (only PBS); B: NIF: AS-LMP (1:2) in PBS and dissolution media with different polymer solution of 100 μg/mL; C: NIF: AS-LMP (1:4) in PBS and dissolution media with different polymer solution of 100 μg/mL; D: NIF: PVP-VA64 (1:6) in PBS and dissolution media with different polymer solution of 100 μg/mL.

Article Snippet: NIF: AS-LMP (1:4) , ASD , – , – , – , – , – , 65 , 65.

Techniques: In Vitro, Dissolution, Polymer

Journal: International Journal of Pharmaceutics: X

Article Title: Double action of HPMCAS as a dry binder and precipitation inhibitor in ASD tablet formulations of nifedipine prepared by hot-melt extrusion

doi: 10.1016/j.ijpx.2025.100475

Figure Lengend Snippet: Compaction analysis of NIF:AS-LMP (1:2) ASD tablets showing their tabletability (A), compressibility (B), compactibility (C) profiles, and Ryshkewitch-Duckworth plot of ln (tensile strength) vs porosity data (mean ± SD, n = 3).

Article Snippet: NIF: AS-LMP (1:4) , ASD , – , – , – , – , – , 65 , 65.

Techniques:

Journal: International Journal of Pharmaceutics: X

Article Title: Double action of HPMCAS as a dry binder and precipitation inhibitor in ASD tablet formulations of nifedipine prepared by hot-melt extrusion

doi: 10.1016/j.ijpx.2025.100475

Figure Lengend Snippet: Average tablet tensile strength data of the ASD tablet formulations of NIF: AS-LMP (1:2) and NIF:AS-LMP (1:4). (A) NIF: AS-LMP (1:2) ASD Tablets (B) NIF: AS-LMP (1:4) ASD Tablets (mean ± SD, n = 3).

Article Snippet: NIF: AS-LMP (1:4) , ASD , – , – , – , – , – , 65 , 65.

Techniques:

Journal: Analytical Chemistry

Article Title: Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry

doi: 10.1021/acs.analchem.5c08059

Figure Lengend Snippet: Histogram of library compounds ( n = 9702). (A) The distribution of molecular weights. (B) Visualization of all 4 properties, as distributed across the library compounds. Dark blue points are inhibitors as defined by the AEMS_Nif assay (≥80% inhibition). (C) AlogP of the library compounds. (D) Polar surface area. (E) Fsp 3 .

Article Snippet: An in-house library of 9702 drug-like compounds (including redundancies; ) was screened at 10 μM for CYP3A4 inhibition using the AEMS_NIF assay.

Techniques: Inhibition

Journal: Analytical Chemistry

Article Title: Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry

doi: 10.1021/acs.analchem.5c08059

Figure Lengend Snippet: Inhibition profiles. (A) Time-course profiles of nifedipine and midazolam metabolism, showing substrate depletion and metabolite formation over the incubation period. (B) Dose–response curves for four well-characterized CYP3A4 inhibitors, ketoconazole, ritonavir, SJ000362065, and Z56791366, measured across three assay formats, LUMI_LUC, AEMS_NIF, and AEMS_LUC, illustrating cross-platform consistency in inhibitory potency.

Article Snippet: An in-house library of 9702 drug-like compounds (including redundancies; ) was screened at 10 μM for CYP3A4 inhibition using the AEMS_NIF assay.

Techniques: Inhibition, Incubation

Journal: Analytical Chemistry

Article Title: Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry

doi: 10.1021/acs.analchem.5c08059

Figure Lengend Snippet: Scatter plot comparing inhibition percentages obtained from the two screening methods. (A) A total of 7360 compounds show strong correlation between methods (R 2 = 0.785). (B) Primary screening resulted in 378 inhibitors (5.2%) in the AEMS_NIF assay and 785 inhibitors (11%) in the LUMI_LUC assay. A total of 350 inhibitors were shared between the two assays.

Article Snippet: An in-house library of 9702 drug-like compounds (including redundancies; ) was screened at 10 μM for CYP3A4 inhibition using the AEMS_NIF assay.

Techniques: Inhibition